BDBM584228 7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2,4-trien-3- yl(hydroxy)methyl)-3,4- dihydroxytetrahydrofuran-2-yl)-3,7- dihydro-4H-pyrrolo[2,3-d]pyrimidin- 4-one O-ethyl oxime::US11524962, Example 21

SMILES CCO\N=c1/[nH]cnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc3CCc3c2)[C@@H](O)[C@H]1O

InChI Key InChIKey=OVNZGAVBPJQRGY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 584228   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM584228(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 148nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM584228(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 153nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
Go to US Patent