BDBM584224 (2S,3S,4R,5R)-2-((R)-1- (bicyclo[4.2.0]octa-1(6),2,4-trien-3- yl)-1-hydroxyethyl)-5-(4-methyl-7H- pyrrolo[2,3-d]pyrimidin-7- yl)tetrahydrofuran-3,4-diol::US11524962, Example 9

SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)[C@](C)(O)c1ccc2CCc2c1

InChI Key InChIKey=AVJDKCLSVKCKCR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 584224   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM584224((2S,3S,4R,5R)-2-((R)-1- (bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 24.3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM584224((2S,3S,4R,5R)-2-((R)-1- (bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 5nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
Go to US Patent