BDBM584222 (2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)- bicyclo[4.2.0]octa-1(6),2,4-trien-3- yl(hydroxy)methyl)tetrahydrofuran- 3,4-diol::US11524962, Example 2

SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc3CCc3c2)[C@@H](O)[C@H]1O

InChI Key InChIKey=PIERCIOPKDBMLC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 584222   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM584222((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 4.10nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM584222((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 2nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
Go to US Patent