BDBM584218 US11524961, Compound 13::US11524961, Compound LW104-N

SMILES O=S(=NC1CC1)(C1CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=HEUJMVSRSAFPDR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 584218   

TargetTyrosine-protein kinase JAK1(Human)
Shanghai Longwood Biopharmaceuticals

US Patent
LigandPNGBDBM584218(US11524961, Compound LW104-N | US11524961, Compoun...)
Affinity DataIC50: 5nMAssay Description:Kinase Assay:Preparation of buffers, the buffer included 50 mM HEPES (pH 7.5), 0.01% Brij-35, 10 mM MgCl2, and 1 mM EGTA.After the buffer was formula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Shanghai Longwood Biopharmaceuticals

US Patent
LigandPNGBDBM584218(US11524961, Compound LW104-N | US11524961, Compoun...)
Affinity DataIC50: 5nMAssay Description:Kinase Assay:Preparation of buffers, the buffer included 50 mM HEPES (pH 7.5), 0.01% Brij-35, 10 mM MgCl2, and 1 mM EGTA.After the buffer was formula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Shanghai Longwood Biopharmaceuticals

US Patent
LigandPNGBDBM584218(US11524961, Compound LW104-N | US11524961, Compoun...)
Affinity DataIC50: 203nMAssay Description:Kinase Assay:Preparation of buffers, the buffer included 50 mM HEPES (pH 7.5), 0.01% Brij-35, 10 mM MgCl2, and 1 mM EGTA.After the buffer was formula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent