BDBM584208 US11524961, Compound 3::US11524961, Compound LW104-C

SMILES N=S(=O)(N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1ccccc1

InChI Key InChIKey=KXADIAHTROQBPF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 584208   

TargetTyrosine-protein kinase JAK1(Human)
Shanghai Longwood Biopharmaceuticals

US Patent
LigandPNGBDBM584208(US11524961, Compound LW104-C | US11524961, Compoun...)
Affinity DataIC50: 55nMAssay Description:Kinase Assay:Preparation of buffers, the buffer included 50 mM HEPES (pH 7.5), 0.01% Brij-35, 10 mM MgCl2, and 1 mM EGTA.After the buffer was formula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Shanghai Longwood Biopharmaceuticals

US Patent
LigandPNGBDBM584208(US11524961, Compound LW104-C | US11524961, Compoun...)
Affinity DataIC50: 55nMAssay Description:Kinase Assay:Preparation of buffers, the buffer included 50 mM HEPES (pH 7.5), 0.01% Brij-35, 10 mM MgCl2, and 1 mM EGTA.After the buffer was formula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Shanghai Longwood Biopharmaceuticals

US Patent
LigandPNGBDBM584208(US11524961, Compound LW104-C | US11524961, Compoun...)
Affinity DataIC50: 427nMAssay Description:Kinase Assay:Preparation of buffers, the buffer included 50 mM HEPES (pH 7.5), 0.01% Brij-35, 10 mM MgCl2, and 1 mM EGTA.After the buffer was formula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent