BDBM582541 (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-(3-oxa-bicyclo[3.1.0]hexan-1-yl)ethynyl)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::US11524956, Example 5

SMILES CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1C#CC12CC1COC2

InChI Key InChIKey=TZOYRHZJCBKRRO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 582541   

TargetEpidermal growth factor receptor(Human)
Newgen Therapeutics

US Patent
LigandPNGBDBM582541(US11524956, Example 5 | (E)-N-(4-(3-chloro-4-fluor...)
Affinity DataIC50: 100nMAssay Description:The assay is performed in a Black 384-well plate (available from Corning). EGFR kinase (is diluted in TR-FRET Dilution Buffer (PV3189, InVitrogen) at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2023
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Newgen Therapeutics

US Patent
LigandPNGBDBM582541(US11524956, Example 5 | (E)-N-(4-(3-chloro-4-fluor...)
Affinity DataIC50: 100nMAssay Description:The assay is performed similarly to the kinase assay for ErbB2 as described above, except ErbB2 kinase protein is used instead of EGFR kinase protein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2023
Entry Details
Go to US Patent