BDBM582516 US11524956, Example 1

SMILES CN(C)C\C=C\C(=O)Nc1cc2cnc(NC3=CCC(F)(Cl)C=C3)nc2cc1C#CC1CCOC1

InChI Key InChIKey=ZOJCXHNJXNIVDF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 582516   

TargetEpidermal growth factor receptor(Human)
Newgen Therapeutics

US Patent
LigandPNGBDBM582516(US11524956, Example 1)
Affinity DataIC50: 100nMAssay Description:The assay is performed in a Black 384-well plate (available from Corning). EGFR kinase (is diluted in TR-FRET Dilution Buffer (PV3189, InVitrogen) at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2023
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Newgen Therapeutics

US Patent
LigandPNGBDBM582516(US11524956, Example 1)
Affinity DataIC50: 100nMAssay Description:The assay is performed similarly to the kinase assay for ErbB2 as described above, except ErbB2 kinase protein is used instead of EGFR kinase protein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2023
Entry Details
Go to US Patent