BDBM581710 (2s,4S)-N-((1s,3S)-3-(3-Cyclopropyl-5-methylphenyl)cyclobutyl)-N-methyl-6-oxo-::US11512059, Example 44

SMILES CN([C@H]1C[C@H](C1)c1cc(C)cc(c1)C1CC1)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2

InChI Key InChIKey=DGKVXTAHMNCGJL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 581710   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581710(US11512059, Example 44 | (2s,4S)-N-((1s,3S)-3-(3-C...)
Affinity DataIC50: 0.520nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581710(US11512059, Example 44 | (2s,4S)-N-((1s,3S)-3-(3-C...)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed