BDBM581529 6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-7-fluoro- 2-(2-fluorophenyl)-4-isopropylisoquinolin-1(2H)-one::US11505536, Example 77

SMILES CCn1c(CO)nn(-c2cc3c(cn(-c4ccccc4F)c(=O)c3cc2F)C(C)C)c1=O

InChI Key InChIKey=VCYLCWJHUGTABX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 581529   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandPNGBDBM581529(US11505536, Example 77 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 1.86nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandPNGBDBM581529(US11505536, Example 77 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed