BDBM581346 US11504381, Compound 29

SMILES CC(C)C[C@H]1CN(CC(N1c1ncc(Cl)cc1N)c1ccc(Cl)cc1)C(=O)CC(O)=O

InChI Key InChIKey=BCURZNRLBFGNAN-UHFFFAOYSA-N

Data  1 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 581346   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581346(US11504381, Compound 29)
Affinity DataKd:  1.00E+3nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581346(US11504381, Compound 29)
Affinity DataKi:  500nMAssay Description:The compounds binding to MDM2 were determined by a quantitative fluorescence polarization binding assay using a recombinant MDM2 protein and fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent