BDBM581336 US11504381, Compound 19::US11548866, Compound 19

SMILES Nc1cc(Cl)cnc1N1CCN(CC1c1ccc(Cl)cc1)C(=O)[C@H]1CCC1C(O)=O

InChI Key InChIKey=GHYBOOXQXXQZDG-UHFFFAOYSA-N

Data  2 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 581336   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581336(US11504381, Compound 19 | US11548866, Compound 19)
Affinity DataKd:  2.30E+5nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581336(US11504381, Compound 19 | US11548866, Compound 19)
Affinity DataKd:  2.30E+5nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581336(US11504381, Compound 19 | US11548866, Compound 19)
Affinity DataKi:  1.40E+5nMAssay Description:The compounds binding to MDM2 were determined by a quantitative fluorescence polarization binding assay using a recombinant MDM2 protein and fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581336(US11504381, Compound 19 | US11548866, Compound 19)
Affinity DataKi:  1.40E+5nMAssay Description:The compounds binding to MDM2 were determined by a quantitative fluorescence polarization binding assay using a recombinant MDM2 protein and fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent