BDBM581007 US11492367, Compound 1

SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C(COP(O)(=O)OC1C2O)OC(C3O)c1cnc2c(N)nccn12

InChI Key InChIKey=BEPRZTSNNLFUCT-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 581007   

TargetStimulator of interferon genes protein(Human)
Janssen Biotech

US Patent
LigandPNGBDBM581007(US11492367, Compound 1)
Affinity DataIC50: 7.31E+3nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′->5′)-monophospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Janssen Biotech

US Patent
LigandPNGBDBM581007(US11492367, Compound 1)
Affinity DataKd:  120nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [138-378](Mouse)
Janssen Biotech

US Patent
LigandPNGBDBM581007(US11492367, Compound 1)
Affinity DataIC50: 2.00E+5nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′->5′)-monophospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent