BDBM580944 US11492357, Compound

SMILES Cc1ccc2c(Nc3ccc(O)c(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12

InChI Key InChIKey=RKNQPHTZMKVIJF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 580944   

LigandPNGBDBM580944(US11492357, Compound)
Affinity DataIC50: 21nMAssay Description:ormula (I) bis-hydrochloride salt prepared in Example 2 (hereinafter referred to as Compound⋅2HCl ) was tested for inhibitory activity against ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM580944(US11492357, Compound)
Affinity DataIC50: 30nMAssay Description:ormula (I) bis-hydrochloride salt prepared in Example 2 (hereinafter referred to as Compound⋅2HCl ) was tested for inhibitory activity against ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM580944(US11492357, Compound)
Affinity DataIC50: 392nMAssay Description:ormula (I) bis-hydrochloride salt prepared in Example 2 (hereinafter referred to as Compound⋅2HCl ) was tested for inhibitory activity against ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent