BDBM580928 5-(4-(3,4-dihydroquinolin-1(2H)-yl)-6- morpholinopyridin-2-yl)pyrimidin-2-amine::US11492348, Compound 140

SMILES Nc1ncc(cn1)-c1cc(cc(n1)N1CCOCC1)N1CCCc2ccccc12

InChI Key InChIKey=WETSTVOERCRPHB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 580928   

LigandPNGBDBM580928(US11492348, Compound 140 | 5-(4-(3,4-dihydroquinol...)
Affinity DataIC50: 120nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580928(US11492348, Compound 140 | 5-(4-(3,4-dihydroquinol...)
Affinity DataIC50: 310nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent