BDBM580915 5-(6-morpholino-4-(1- phenylcyclopropyl)pyridin-2-yl)pyrimidin-2- amine::US11492348, Compound 127

SMILES Nc1ncc(cn1)-c1cc(cc(n1)N1CCOCC1)C1(CC1)c1ccccc1

InChI Key InChIKey=YUAITLJOHKMDAE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 580915   

LigandPNGBDBM580915(US11492348, Compound 127 | 5-(6-morpholino-4-(1- p...)
Affinity DataIC50: 56nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580915(US11492348, Compound 127 | 5-(6-morpholino-4-(1- p...)
Affinity DataIC50: 380nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580915(US11492348, Compound 127 | 5-(6-morpholino-4-(1- p...)
Affinity DataIC50: 130nMAssay Description:The substrate was prepared in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent