BDBM580031 US11485736, Compound Table 3.15

SMILES COc1ncnc(C2CC2)c1-c1ncc2cnn(Cc3ccc(cc3)-c3nc(cn3C(C)C)C(F)(F)F)c2n1

InChI Key InChIKey=KCBWAFJCKVKYHO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 580031   

TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM580031(US11485736, Compound Table 3.15)
Affinity DataIC50: 11nMAssay Description:Inhibition of USP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetWD repeat-containing protein 48(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM580031(US11485736, Compound Table 3.15)
Affinity DataIC50: 21nMAssay Description:Inhibition of USP1-UAF1 complex (unknown origin) using Ub-7-amido-4-methylcoumarin as substrate incubated for 2 hrs by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM580031(US11485736, Compound Table 3.15)
Affinity DataIC50: 55nMAssay Description:Deubiquitinase activity was measured using ubiquitin-rhodamine 110 as a substrate. Cleavage of the amide bond between rhodamine and the c-terminal gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent