BDBM579486 US11484525, Compound Naloxone

SMILES C=CCN1CC[C@]23c4c5ccc(c4O[C@H]2C(=O)CC[C@]3([C@H]1C5)O)O

InChI Key InChIKey=UZHSEJADLWPNLE-UHFFFAOYSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 579486   

TargetKappa-type opioid receptor(Human)
University of California

US Patent
LigandPNGBDBM579486(US11484525, Compound Naloxone)
Affinity DataKi:  3.70nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
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TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandPNGBDBM579486(US11484525, Compound Naloxone)
Affinity DataKi:  4.10nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
University of California

US Patent
LigandPNGBDBM579486(US11484525, Compound Naloxone)
Affinity DataKi:  23nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
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TargetDelta-type opioid receptor(Human)
University of California

US Patent
LigandPNGBDBM579486(US11484525, Compound Naloxone)
Affinity DataKi:  57nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent