BDBM578517 3-methoxy-5,5- dimethyl-3-(4- methylthiazol-2- yl)-6- oxocyclohex-1- enecarbonitrile (Enantiomer A)::US11479539, Compound 142::US11479539, Compound 36

SMILES COC1(CC(C)(C)C(=O)C(=C1)C#N)c1nc(C)cs1

InChI Key InChIKey=IQMKVOVHZXDBGS-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 578517   

Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandPNGBDBM578517(US11479539, Compound 36 | US11479539, Compound 142...)
Affinity DataEC50:  60nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent

Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandPNGBDBM578517(US11479539, Compound 36 | US11479539, Compound 142...)
Affinity DataEC50:  96nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent