BDBM578516 3-ethoxy-5,5- dimethyl-6-oxo- 3-(3- (trifluoromethyl)py- ridin-2- yl)cyclohex-1- enecarbonitrile (Enantiomer A)::US11479539, Compound 143::US11479539, Compound 35

SMILES CCOC1(CC(C)(C)C(=O)C(=C1)C#N)c1ncccc1C(F)(F)F

InChI Key InChIKey=LCQAGOBGWBNOJF-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 578516   

Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandPNGBDBM578516(US11479539, Compound 35 | US11479539, Compound 143...)
Affinity DataEC50:  139nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent

Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandPNGBDBM578516(US11479539, Compound 35 | US11479539, Compound 143...)
Affinity DataEC50:  39nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent