BDBM577719 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-1-methyl-1,10,11,13,14,15-hexahydropyrazolo[4′,3′:7,8][1,4]oxazacycloundecino[6,5,4-hi]indole-8-carboxylic acid::US11478451, Example 125

SMILES CCc1nn(C)c2CCCOCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34

InChI Key InChIKey=UHVHAZALLKRBMD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 577719   

LigandPNGBDBM577719(US11478451, Example 125 | (rac)-4-chloro-3-ethyl-7...)
Affinity DataIC50: 1.40nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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TargetBcl-2-like protein 1 [1-212]/Bad BH3 Peptide(Human)
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US Patent
LigandPNGBDBM577719(US11478451, Example 125 | (rac)-4-chloro-3-ethyl-7...)
Affinity DataIC50: 2.00E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-XL and the BH3 domain of Bad (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent

LigandPNGBDBM577719(US11478451, Example 125 | (rac)-4-chloro-3-ethyl-7...)
Affinity DataIC50: 2.00E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent