BDBM577706 (+)-4′-chloro-3′-ethyl-7′-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2′-methyl-2′,10′,11′,15′-tetrahydro-13′H-spiro[cyclopropane-1,12′-pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole]-8′-carboxylic acid-N-ethylethanamine salt (Enantiomer 2)::US11478451, Example 111

SMILES CCc1c-2c(COCC3(CC3)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C

InChI Key InChIKey=KVOJNOZDXGZAIE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 577706   

LigandPNGBDBM577706(US11478451, Example 111 | (+)-4′-chloro-3...)
Affinity DataIC50: 19nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent

TargetBcl-2-like protein 1 [1-212]/Bad BH3 Peptide(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM577706(US11478451, Example 111 | (+)-4′-chloro-3...)
Affinity DataIC50: 1.60E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-XL and the BH3 domain of Bad (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent

LigandPNGBDBM577706(US11478451, Example 111 | (+)-4′-chloro-3...)
Affinity DataIC50: 1.80E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent