BDBM577582 (R)-2-((1-Methyl-3-(oxetan-3-yloxy)-1 H-pyrazol-4-yl)amino)-7-(tetrahydrofuran-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carbonitrile::WO2022263472, Example 51

SMILES CC(C)Oc1nn(cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@H]3C)c2n1)[C@@H](C)C#N

InChI Key InChIKey=NMXYDWJXPZEWMJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 577582   

LigandPNGBDBM577582(WO2022263472, Example 51 | (R)-2-((1-Methyl-3-(oxe...)
Affinity DataIC50: 5nMAssay Description: LRRK2(human) is incubated with 50 mM HEPES pH 8.0, 0.2 mM EDTA, 0.01 %Brij-35, 1% (w/v) BSA, 5 mM DTT, 250 Mm RLGRDKYKTLRQIRQ, 10 mM Magnesium aceta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
WIPO WO2022263472