BDBM577554 2-[[1-[(1 R)-2,2-Difluoro-1-methyl-ethyl]-3-(oxetan-3-yloxy)pyrazol-4-yl]amino]-7-[(3R,4R)-4-methyltetrahydrofuran-3-yl]pyrrolo[2,3-d]pyrimidine-6-carbonitrile::WO2022263472, Example 4

SMILES C[C@H](C(F)F)n1cc(Nc2ncc3cc(C#N)n([C@H]4COC[C@@H]4C)c3n2)c(OC2COC2)n1

InChI Key InChIKey=IDMWRZBIQSWWLI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 577554   

LigandPNGBDBM577554(WO2022263472, Example 4 | 2-[[1-[(1 R)-2,2-Difluor...)
Affinity DataIC50: 1nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
WIPO WO2022263472

LigandPNGBDBM577554(WO2022263472, Example 4 | 2-[[1-[(1 R)-2,2-Difluor...)
Affinity DataIC50: 1nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
WIPO WO2022263472

LigandPNGBDBM577554(WO2022263472, Example 4 | 2-[[1-[(1 R)-2,2-Difluor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed