BDBM577168 4-(7-Cyclopropyl-8-oxo-5,6,7,8-tetrahydro[1,3]thiazolo[4',5':4,5]pyrrolo[1,2-a]pyrazin-9-yl)-2-fluorobenzonitrile::US11472805, Example 72

SMILES Fc1cc(ccc1C#N)-c1c2C(=O)N(CCn2c2scnc12)C1CC1

InChI Key InChIKey=CPGLQQFUYMJRLF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 577168   

LigandPNGBDBM577168(US11472805, Example 72 | 4-(7-Cyclopropyl-8-oxo-5,...)
Affinity DataIC50: 3.53nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577168(US11472805, Example 72 | 4-(7-Cyclopropyl-8-oxo-5,...)
Affinity DataIC50: 4.36nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577168(US11472805, Example 72 | 4-(7-Cyclopropyl-8-oxo-5,...)
Affinity DataIC50: 15.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577168(US11472805, Example 72 | 4-(7-Cyclopropyl-8-oxo-5,...)
Affinity DataIC50: 90.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent