BDBM577060 1-(3-(4-amino-1-isopropyl- 1H-pyrazolo[4,3-c]pyridin-3- yl)-5-cyclopropylisoxazol-4- yl)-3-methylimidazolidin-2- one::US11472802, Example 64

SMILES CC(C)n1nc(-c2noc(C3CC3)c2N2CCN(C)C2=O)c2c(N)nccc12

InChI Key InChIKey=INCPZWHAKUZRKZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 577060   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM577060(1-(3-(4-amino-1-isopropyl- 1H-pyrazolo[4,3-c]pyrid...)
Affinity DataIC50: 1.70nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577060(1-(3-(4-amino-1-isopropyl- 1H-pyrazolo[4,3-c]pyrid...)
Affinity DataIC50: 9.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577060(1-(3-(4-amino-1-isopropyl- 1H-pyrazolo[4,3-c]pyrid...)
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM577060(1-(3-(4-amino-1-isopropyl- 1H-pyrazolo[4,3-c]pyrid...)
Affinity DataIC50: 18.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577060(1-(3-(4-amino-1-isopropyl- 1H-pyrazolo[4,3-c]pyrid...)
Affinity DataIC50: 6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent