BDBM577048 7-chloro-3-(5-cyclopropyl- 4-(1-ethyl-1H-pyrazol-3- yl)isoxazol-3-yl)-1- isopropyl-1H-pyrazolo[4,3- c]pyridin-4-amine::US11472802, Example 54

SMILES CCn1ccc(n1)-c1c(noc1C1CC1)-c1nn(C(C)C)c2c(Cl)cnc(N)c12

InChI Key InChIKey=LWNYGBPSNNDSSL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 577048   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM577048(7-chloro-3-(5-cyclopropyl- 4-(1-ethyl-1H-pyrazol-3...)
Affinity DataIC50: 0.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577048(7-chloro-3-(5-cyclopropyl- 4-(1-ethyl-1H-pyrazol-3...)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577048(7-chloro-3-(5-cyclopropyl- 4-(1-ethyl-1H-pyrazol-3...)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM577048(7-chloro-3-(5-cyclopropyl- 4-(1-ethyl-1H-pyrazol-3...)
Affinity DataIC50: 6.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM577048(7-chloro-3-(5-cyclopropyl- 4-(1-ethyl-1H-pyrazol-3...)
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent