BDBM5768 (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(phenyl)methanone::5-benzoyl-4-butoxy-1H-pyrazolo[3,4-b]pyridine::CHEMBL14619::SQ-67563::pyrazolo[3,4-b]pyridine deriv.

SMILES CCCCOc1c(cnc2[nH]ncc12)C(=O)c1ccccc1

InChI Key InChIKey=DARUYCQCOQATNX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 5768   

LigandPNGBDBM5768(CHEMBL14619 | (4-butoxy-1H-pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 150nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandPNGBDBM5768(CHEMBL14619 | (4-butoxy-1H-pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 110nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandPNGBDBM5768(CHEMBL14619 | (4-butoxy-1H-pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 2.50E+4nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandPNGBDBM5768(CHEMBL14619 | (4-butoxy-1H-pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 110nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM5768(CHEMBL14619 | (4-butoxy-1H-pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed