BDBM576621 US11472776, Example 9::US20240158357, Example 9

SMILES CN1CC(C1)C(=O)Nc1ccc(cc1)-c1nc2ccsc2c(=O)[nH]1

InChI Key InChIKey=VDAOLXPMSPZAOX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 576621   

LigandPNGBDBM576621(US11472776, Example 9 | US20240158357, Example 9)
Affinity DataIC50: 6.89E+3nMAssay Description:AlphaLisa Assay (ALA) was used as a primary screen for identifying compounds that inhibit tau oligomer formation. It is a bead based assay that only ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

LigandPNGBDBM576621(US11472776, Example 9 | US20240158357, Example 9)
Affinity DataIC50: 6.24E+4nMAssay Description:Confirmatory Assay (CONFA) used as a secondary screen for confirming the mechanism of action of compounds identified as hits using the ALA assay. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

TargetMicrotubule-associated protein tau(Human)
Oligomerix

US Patent
LigandPNGBDBM576621(US11472776, Example 9 | US20240158357, Example 9)
Affinity DataIC50: 1.71E+4nMAssay Description:AlphaLisa Assay (ALA) was used as a primary screen for identifying compounds that inhibit tau oligomer formation. It is a bead based assay that only ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetMicrotubule-associated protein tau(Human)
Oligomerix

US Patent
LigandPNGBDBM576621(US11472776, Example 9 | US20240158357, Example 9)
Affinity DataIC50: 5.70E+4nMAssay Description:Confirmatory Assay (CONFA) used as a secondary screen for confirming the mechanism of action of compounds identified as hits using the ALA assay. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent