BDBM576465 US11471446, Compound DBA-6

SMILES NC(=O)c1sc2nccc(N3CCCN(CC3)c3ccccc3)c2c1N

InChI Key InChIKey=DEXAFBASLBZBIA-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576465   

TargetCyclin-dependent kinase 8(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM576465(US11471446, Compound DBA-6)
Affinity DataIC50: 31nMAssay Description:Inhibition of CDK8 in human HEK293 cells measured by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8/19(Human)
Lu License

US Patent
LigandPNGBDBM576465(US11471446, Compound DBA-6)
Affinity DataEC50:  180nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent