BDBM576408 4-(3,5-dimethyl- 1H-pyrazol-4-yl)-6-methyl-1,3-benzothiazole::WO2022112919, Example 13

SMILES Cc1n[nH]c(C)c1-c1cc(C)cc2scnc12

InChI Key InChIKey=KRZGNEDYAPVJNL-UHFFFAOYSA-N

Data  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576408   

TargetTransthyretin(Human)
Pfizer

WIPO
LigandPNGBDBM576408(4-(3,5-dimethyl- 1H-pyrazol-4-yl)-6-methyl-1,3-ben...)
Affinity DataEC50:  21nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022112919

TargetTransthyretin(Human)
Pfizer

WIPO
LigandPNGBDBM576408(4-(3,5-dimethyl- 1H-pyrazol-4-yl)-6-methyl-1,3-ben...)
Affinity DataKd:  58nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022112919