BDBM576401 4-(3,5-dimethyl-1 H-pyrazol-4-yl)-2-methyl-1,3-benzothiazole::WO2022112919, Example 6

SMILES Cc1nc2c(cccc2s1)-c1c(C)n[nH]c1C

InChI Key InChIKey=AGLCHTLJCMFORB-UHFFFAOYSA-N

Data  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576401   

TargetTransthyretin(Human)
Pfizer

WIPO
LigandPNGBDBM576401(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-2-methyl-1,3-ben...)
Affinity DataKd:  574nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022112919

TargetTransthyretin(Human)
Pfizer

WIPO
LigandPNGBDBM576401(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-2-methyl-1,3-ben...)
Affinity DataEC50:  1.78E+3nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022112919