BDBM576399 4-(3,5-dimethyl-1 H-pyrazol-4-yl)-7-(trifluoro ethyl)-1,3-benzothiazole::WO2022112919, Example 4

SMILES Cc1n[nH]c(C)c1-c1ccc(c2scnc12)C(F)(F)F

InChI Key InChIKey=VOBVTPYKRSIUDK-UHFFFAOYSA-N

Data  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576399   

TargetTransthyretin(Human)
Pfizer

WIPO
LigandPNGBDBM576399(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-7-(trifluoro eth...)
Affinity DataEC50:  40nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022112919

TargetTransthyretin(Human)
Pfizer

WIPO
LigandPNGBDBM576399(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-7-(trifluoro eth...)
Affinity DataKd:  49nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022112919