BDBM576022 (1-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- yl)methanamine::US11466017, Example 9::US11529347, Compound 10

SMILES CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=KZCSSNUZWXPJCN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576022   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
University Of Texas

US Patent
LigandPNGBDBM576022(US11529347, Compound 10 | US11466017, Example 9 | ...)
Affinity DataIC50: 367nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

US Patent
LigandPNGBDBM576022(US11529347, Compound 10 | US11466017, Example 9 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent