BDBM576002 7-{6-[endo- 3-amino-8- azabicyclo[3.2.1] octan-8-yl]-5-methyl- 1H-pyrazolo[3,4- b]pyrazin-3-yl}-8- chloro-N,N- dimethylquinoxalin- 2-amine::US11466016, Example 136

SMILES CN(C)c1cnc2ccc(-c3n[nH]c4nc(N5[C@H]6CC[C@@H]5C[C@H](N)C6)c(C)nc34)c(Cl)c2n1

InChI Key InChIKey=SMHJWOKHUPJLKF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 576002   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM576002(US11466016, Example 136 | 7-{6-[endo- 3-amino-8- ...)
Affinity DataIC50: 9nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent