BDBM575996 US11466016, Example 130::{6-[(1S,2S,3S,5R)- 3-amino-2-fluoro-8- azabicyclo[3.2.1] octan-8-yl]-3- [5-chloro-3- (dimethylamino) quinoxalin-6-yl]-1H- pyrazolo[3,4- b]pyrazin-5- yl}methanol

SMILES CN(C)c1cnc2ccc(-c3n[nH]c4nc(N5[C@@H]6CC[C@@H]5[C@@H](F)[C@@H](N)C6)c(CO)nc34)c(Cl)c2n1

InChI Key InChIKey=JABIEEOYCYLUIX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575996   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575996(US11466016, Example 130 | {6-[(1S,2S,3S,5R)- 3-am...)
Affinity DataIC50: 9.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent