BDBM575995 5-{6- [(1R,2S,3S,5S)-3- amino-2-fluoro-8- azabicyclo[3.2.1] octan-8-yl]-5- (hydroxymethyl)- 1H-pyrazolo[3,4- b]pyrazin-3-yl}-4- chloro-2-methyl-2H- indazole-3- carbonitrile::US11466016, Example 129

SMILES Cn1nc2ccc(-c3n[nH]c4nc(N5[C@H]6CC[C@@H]5[C@@H](F)[C@@H](N)C6)c(CO)nc34)c(Cl)c2c1C#N

InChI Key InChIKey=RXKDROMOZYKUMQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575995   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575995(US11466016, Example 129 | 5-{6- [(1R,2S,3S,5S)-3-...)
Affinity DataIC50: 5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent