BDBM575991 6-[3,9- diazabicyclo[3.3.1] nonan-9-yl]-3-(3,4- dichloro-2-methyl- 2H-indazol-5-yl)- 1H-pyrazolo[3,4- b]pyrazin-5- yl}methanol::US11466016, Example 125

SMILES Cn1nc2ccc(-c3n[nH]c4nc(N5[C@H]6CCC[C@@H]5CNC6)c(CO)nc34)c(Cl)c2c1Cl

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575991   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575991(US11466016, Example 125 | 6-[3,9- diazabicyclo[3....)
Affinity DataIC50: 7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent