BDBM575990 5-{6- [(1R,2S,3S,5S)-3- amino-2-fluoro-8- azabicyclo [3.2.1]octan- 8-yl]-5-methyl- 1H-pyrazolo[3,4- b]pyrazin-3-yl}-4- chloro-2-methyl-2H- indazole-3- carbonitrile::US11466016, Example 124

SMILES Cc1nc2c(n[nH]c2nc1N1[C@H]2CC[C@@H]1[C@@H](F)[C@@H](N)C2)-c1ccc2nn(C)c(C#N)c2c1Cl

InChI Key InChIKey=IJUKUBJYKHCLAG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575990   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575990(US11466016, Example 124 | 5-{6- [(1R,2S,3S,5S)-3-...)
Affinity DataIC50: 8.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent