BDBM575965 7-{6-[(1R,2S,3S,5S)- 3-amino-2-fluoro-8- azabicyclo[3.2.1]octan- 8-yl]-5-methyl-1H- pyrazolo[3,4-b]pyrazin- 3-yl}-8-chloro-N,N- dimethylquinoxalin-2- amine::US11466016, Example 96

SMILES CN(C)c1cnc2ccc(-c3n[nH]c4nc(N5[C@H]6CC[C@@H]5[C@@H](F)[C@@H](N)C6)c(C)nc34)c(Cl)c2n1

InChI Key InChIKey=DNRZIJRKLANKIX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575965   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575965(US11466016, Example 96 | 7-{6-[(1R,2S,3S,5S)- 3-am...)
Affinity DataIC50: 4.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent