BDBM575962 (1R,2S,3S,5S)-8-[3-(3,4- Dichloro-2-methyl-2H- indazol-5-yl)-5-methyl- 1H-pyrazolo[3,4-b]pyrazin- 6-yl]-2-fluoro-8-aza- bicyclo[3.2.1]octan-3- amine::US11466016, Example 93

SMILES Cc1nc2c(n[nH]c2nc1N1[C@H]2CC[C@@H]1[C@@H](F)[C@@H](N)C2)-c1ccc2nn(C)c(Cl)c2c1Cl

InChI Key InChIKey=FQTJHOCFUNBJQK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575962   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575962(US11466016, Example 93 | (1R,2S,3S,5S)-8-[3-(3,4- ...)
Affinity DataIC50: 3.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent