BDBM575959 US11466016, Example 88::{6-[endo-3-amino-8- azabicyclo[3.2.1]octan-8- yl]-3-(3,4-dichloro-2- methyl-2H-indazol-5-yl)- 1H-pyrazolo[3,4- b]pyrazin-5-yl}methanol

SMILES Cn1nc2ccc(-c3n[nH]c4nc(N5[C@H]6CC[C@@H]5C[C@H](N)C6)c(CO)nc34)c(Cl)c2c1Cl

InChI Key InChIKey=MNQQUHYYPSDDOV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575959   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575959(US11466016, Example 88 | {6-[endo-3-amino-8- azabi...)
Affinity DataIC50: 7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent