BDBM575957 US11466016, Example 86::{6-[3,8- diazabicyclo[3.2.1]octan-8- yl]-3-(3,4-dichloro-2- methyl-2H-indazol-5-yl)- 1H-pyrazolo[3,4-b]pyrazin- 5-yl}methanol

SMILES Cn1nc2ccc(-c3n[nH]c4nc(N5[C@H]6CC[C@@H]5CNC6)c(CO)nc34)c(Cl)c2c1Cl

InChI Key InChIKey=IYYMXIQAZUYAOD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575957   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575957(US11466016, Example 86 | {6-[3,8- diazabicyclo[3.2...)
Affinity DataIC50: 7.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent