BDBM575950 US11466016, Example 79::{6-[(1R,2S,3S,5S)-3- amino-2-fluoro-8- azabicyclo[3.2.1]octan-8- yl]-3-(4-chloro-2-methyl- 2H-indazol-5-yl)-1H- pyrazolo[3,4-b]pyrazin-5- yl}methanol

SMILES Cn1cc2c(Cl)c(ccc2n1)-c1n[nH]c2nc(N3[C@H]4CC[C@@H]3[C@@H](F)[C@@H](N)C4)c(CO)nc12

InChI Key InChIKey=OYCTYGRYBSMUGZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575950   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575950(US11466016, Example 79 | {6-[(1R,2S,3S,5S)-3- amin...)
Affinity DataIC50: 9.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent