BDBM575935 (1R,2S,3S,5S)-8-[7-(4- chloro-2-methyl-2H- indazol-5-yl)-5H- pyrrolo[2,3-b]pyrazin-3- yl]-2-fluoro-8- azabicyclo[3.2.1]octan- 3-amine::US11466016, Example 64

SMILES Cn1cc2c(Cl)c(ccc2n1)-c1c[nH]c2nc(cnc12)N1[C@H]2CC[C@@H]1[C@@H](F)[C@@H](N)C2

InChI Key InChIKey=XSEQAEZYMSFVOU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575935   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575935(US11466016, Example 64 | (1R,2S,3S,5S)-8-[7-(4- ch...)
Affinity DataIC50: 7.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent