BDBM575934 5-{3-[endo-3-amino-8- azabicyclo[3.2.1]octan- 8-yl]-5H-pyrrolo[2,3- b]pyrazin-7-yl}-4- chloro-2-methyl-2H- indazole-3-carbonitrile::US11466016, Example 62

SMILES Cn1nc2ccc(-c3c[nH]c4nc(cnc34)N3[C@H]4CC[C@@H]3C[C@H](N)C4)c(Cl)c2c1C#N

InChI Key InChIKey=JRHIFWQYUNDUMP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575934   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575934(US11466016, Example 62 | 5-{3-[endo-3-amino-8- aza...)
Affinity DataIC50: 7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent