BDBM575911 US11466016, Example 39::endo-8-{7-[7- chloro-2- (oxolan-3-yl)- 1,3-benzothiazol- 6-yl]-5H- pyrrolo[2,3-b] pyrazin-3-yl}-8- azabicyclo[3.2.1] octan-3-amine, dihydrochloride salt

SMILES N[C@H]1CC2CC[C@@H](C1)N2c1cnc2c(c[nH]c2n1)-c1ccc2nc(sc2c1Cl)C1CCOC1

InChI Key InChIKey=QUUGZTPTYLKXAW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575911   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575911(US11466016, Example 39 | endo-8-{7-[7- chloro-2- (...)
Affinity DataIC50: 6.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent