BDBM575908 2-(5-{3-[endo- 3-amino-8- azabicyclo[3.2.1] octan- 8-yl]-5H-pyrrolo [2,3-b]pyrazin- 7-yl}-3,4- dichloro-2H- indazol-2- yl)ethan-1-ol::US11466016, Example 36

SMILES N[C@@H]1C[C@@H]2CC[C@H](C1)N2c1cnc2c(c[nH]c2n1)-c1ccc2nn(CCO)cc2c1Cl

InChI Key InChIKey=YOJPAQHPJUEWRD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575908   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575908(US11466016, Example 36 | 2-(5-{3-[endo- 3-amino-8-...)
Affinity DataIC50: 6nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent