BDBM575886 US11466016, Example 15::endo-8-[7-(7- chloro-2- methyl-1,3- benzothiazol- 6-yl)-5H-pyrrolo [2,3-b]pyrazin- 3-yl]-8- azabicyclo[3.2.1] octan-3-amine, methanesulfonic acid salt

SMILES Cc1nc2ccc(-c3c[nH]c4nc(cnc34)N3[C@H]4CC[C@@H]3C[C@H](N)C4)c(Cl)c2s1

InChI Key InChIKey=XSGALAHFMFTPPL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575886   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575886(US11466016, Example 15 | endo-8-[7-(7- chloro-2- m...)
Affinity DataIC50: 5.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent