BDBM575884 US11466016, Example 13::endo-8-[7-(7- chloro-1,3- benzothiazol- 6-yl)-5H- pyrrolo[2,3-b] pyrazin-3-yl]-8- azabicyclo [3.2.1]octan- 3-amine, methanesulfonic acid salt

SMILES N[C@@H]1C[C@@H]2CC[C@H](C1)N2c1cnc2c(c[nH]c2n1)-c1ccc2ncsc2c1Cl

InChI Key InChIKey=PYUNNZRQXNMGQF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575884   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575884(US11466016, Example 13 | endo-8-[7-(7- chloro-1,3-...)
Affinity DataIC50: 6.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent