BDBM575657 3-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5]decan-8-yl)-6- (hydroxymethyl)pyrazin-2-yl)thio)-2- chloro-6,7,8,9-tetrahydro- 5H-pyrido[3,2-b]indol-8-ol formate::US11459340, Compound 39

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3cc4[nH]c5CCC(O)Cc5c4nc3Cl)nc2CO)[C@@H]1N

InChI Key InChIKey=XXGUSYVNKGOSDD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575657   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM575657(US11459340, Compound 39 | 3-((5-((3S,4S)-4-amino-3...)
Affinity DataIC50: 3.5nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
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